Cartridge lasts up to one year. As with any filtration product, replacement life cycle depends on the individual conditions and needs of the home. Compatible with any HVAC system, no additional power source needed. Removes OVER 95% of particles ranging in size down to 0.3 micron. Removes OVER 90% of bioaerosols and microorganisms down to 0.01 micron. Hospital inpatient care/general surgery level filtration.